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Uptodate Reference Title
Rapid oral progesterone desensitization*
Rapid oral progesterone desensitization*
Protocol step
Oral capsules dose (mcg)
Number of capsules
Total dose
Time interval (minutes)
1
1
1
1
30
2
1
2
2
30
3
1
5
5
30
4
10
1
10
30
5
10
2
20
30
6
10
5
50
30
7
100
1
100
30
Note that this protocol has been performed in a very small number of patients by experienced allergy specialists. The efficacy in larger numbers of patients awaits further study. UpToDate suggests that allergy specialists supervise such protocols whenever possible.
* With use of capsules made at a compounding pharmacy.
Original figure modified for this publication. Reproduced from: Prieto-Garcia A, Sloane DE, Gargiulo AR, et al. Autoimmune progesterone dermatitis: Clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertil Steril 2011; 95:1121.e9. Table used with the permission of Elsevier Inc. All rights reserved.
