| Generic compound | ADF mechanism | Dosages available | Deterrence label | Comments |
| Oxycodone | ||||
| OxyContin (oxycodone extended-release) | Difficult to crush and if dissolved, the tablet forms a viscous gel that is difficult to inject IV. | 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg | IV, nasal | |
| Xtampza ER (oxycodone extended-release) | Capsules contain microspheres of oxycodone and inactive ingredients that hinder dosage dumping via intranasal and oral abuse. Microspheres cannot be readily dissolved and will solidify within a needle to prevent injection. | 9 mg, 13.5 mg, 18 mg, 27 mg, 36 mg | IV, nasal, oral | A good option for patients unable to swallow tablets. The capsules can be opened so that the microspheres may be safely poured into a feeding tube, sprinkled onto food, or placed directly into the mouth.[1] |
| Targiniq ER, Targin (oxycodone extended-release plus naloxone) | Contains naloxone (opioid antagonist) which is not active when taken orally, but blocks opioid associated euphoria when injected or inhaled | 10/5 mg, 20/10 mg, 40/20 mg | IV, nasal | Available in Canada, not available in the United States |
| Hydrocodone | ||||
| Hysingla ER (hydrocodone extended-release) | Difficult to crush and if dissolved, the tablet forms a viscous gel that is difficult to inject IV. | 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, 100 mg, 120 mg | IV, nasal, oral | |
