Your activity: 26 p.v.
< Back
your limit has been reached. plz Donate us to allow your ip full access, Email: sshnevis@outlook.com

Starting dosing regimens for sirolimus in neonates and infants

Starting dosing regimens for sirolimus in neonates and infants
Age group (months) Dose (mg/m2/dose every 12 hours)
Target range: 6 to 10 ng/mL
(predose concentration or "trough")		 Target range: 10 to 15 ng/mL
(predose concentration or "trough")
0 to 1 0.28 0.4
1 to 2 0.34 0.5
2 to 3 0.4 0.6
3 to 4 0.46 0.7
4 to 6 0.58 0.9
6 to 9 0.7 1.1
9 to 12 0.82 1.3
12 to 24 1 1.4
Starting dosing regimens for sirolimus in neonates and infants. Simulations based on pharmacokinetic data in patient with vascular anomalies.
Data from: Mizuno T, Fukuda T, Emoto C, et al. Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies. Pediatr Blood Cancer 2017.
Graphic 115485 Version 1.0