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Frequency of adverse effects from RBC transfusion placed in context relative to the risks of other hazards

Frequency of adverse effects from RBC transfusion placed in context relative to the risks of other hazards
Risk is depicted on a logarithmic scale. Shaded bars represent the risk of the adverse event per RBC unit transfused, and unshaded bars represent the risk for fatality per person per year for various life events. Refer to the source document for additional details of these risk calculations. More recent data about flight safety are available at https://www.bts.gov/content/us-air-carrier-safety-data; these suggest that the risk of death from airline crashes is lower than depicted here. Refer to UpToDate for discussions of factors that impact these transfusion-associated risks, and our approaches to evaluating their presence, reducing their frequency, and treating them when they occur.
RBC: red blood cell; HIV: human immunodeficiency virus; HCV: hepatitis C virus; HBV: hepatitis B virus; TRALI: transfusion-related acute lung injury; TACO: transfusion-associated circulatory overload.
References:
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  9. Li G, Rachmale S, Kojicic M, et al. Incidence and transfusion risk factors for transfusion-associated circulatory overload among medical intensive care unit patients. Transfusion 2011; 51:338.
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  14. US Food and Drug Administration. Fatalities reported to FDA following blood collection and transfusion: Annual summary for fiscal year 2010. US Food and Drug Administration, Silver Spring, MD 2011.
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  16. Kohn L. To err is human: An interview with the Institute of Medicine's Linda Kohn. Jt Comm J Qual Improv 2000; 26:227.
  17. Minino AM, Murphy SL, Xu J, Kochanek, KD. Deaths: Final data for 2008. National Center for Health Statistics, Hyattsville, MD 2011.
  18. https://www.weather.gov/safety/lightning-fatalities (Accessed on April 9, 2021).
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From Annals of Internal Medicine, Carson JL, Grossman BJ, Kleinman S, et al. Red blood cell transfusion: A clinical practice guideline from the AABB*. Ann Intern Med 2012; 157(1):49-58. Copyright © 2012 American College of Physicians. All Rights Reserved. Reprinted with the permission of American College of Physicians, Inc.
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