| Nonpregnant* | First trimester | Second trimester | Third trimester | References |
Hematology |
Erythropoietin¶ (units/L) | 4 to 27 | 12 to 25 | 8 to 67 | 14 to 222 | 1 to 3 |
Ferritin¶ (ng/mL) | 10 to 150Δ | 6 to 130 | 2 to 230 | 10 to 116 | 1 to 8 |
Folate, red blood cell (ng/mL) | 150 to 450 | 137 to 589 | 94 to 828 | 109 to 663 | 6, 9, 10 |
Folate, serum (ng/mL) | 5.4 to 18.0 | 2.6 to 15.0 | 0.8 to 24.0 | 1.4 to 20.7 | 1, 6, 9 to 13 |
Haptoglobin (mg/mL) | 25 to 250 | 130 +/- 43 | 115 +/- 50 | 135 +/- 65 | 31 |
Hemoglobin¶ (g/dL) | 12.0 to 15.8Δ | 11.0 to 13.9 | 10.6 to 14.8 | 9.5 to 15.0 | 2, 3, 6, 7, 13, 32 |
Hematocrit¶ (%) | 35.4 to 44.4 | 33.0 to 41.0 | 32.0 to 39.0 | 30.0 to 40.0 | 1, 2, 5, 6, 13 to 15, 32 |
Iron, total binding capacity¶ (mcg/dL) | 251 to 406 | 278 to 403 | Not reported | 359 to 609 | 7 |
Iron, serum¶ (mcg/dL) | 41 to 141 | 72 to 143 | 44 to 178 | 30 to 193 | 2, 7 |
Mean corpuscular hemoglobin (pg/cell) | 27 to 32 | 30 to 32 | 30 to 33 | 29 to 32 | 5 |
Mean corpuscular volume (xm3) | 79 to 93 | 81 to 96 | 82 to 97 | 81 to 99 | 5, 6, 13, 14 |
Platelet (x109/L) | 165 to 415 | 174 to 391 | 155 to 409 | 146 to 429 | 5, 6, 14, 16, 17 |
Mean platelet volume (mcm3) | 6.4 to 11.0 | 7.7 to 10.3 | 7.8 to 10.2 | 8.2 to 10.4 | 5 |
Red blood cell count (x106/mm3) | 4.00 to 5.20Δ | 3.42 to 4.55 | 2.81 to 4.49 | 2.71 to 4.43 | 5, 6, 13, 14 |
Red cell distribution width (%) | <14.5 | 12.5 to 14.1 | 13.4 to 13.6 | 12.7 to 15.3 | 5 |
White blood cell count (x103/mm3) | 3.5 to 9.1 | 5.7 to 13.6 | 5.6 to 14.8 | 5.9 to 16.9 | 5, 6, 13, 14, 18 |
Neutrophils (x103/mm3) | 1.4 to 4.6 | 3.6 to 10.1 | 3.8 to 12.3 | 3.9 to 13.1 | 5, 14, 16, 18 |
Lymphocytes (x103/mm3) | 0.7 to 4.6 | 1.1 to 3.6 | 0.9 to 3.9 | 1.0 to 3.6 | 5, 14, 16, 18 |
Monocytes (x103/mm3) | 0.1 to 0.7 | 0.1 to 1.1 | 0.1 to 1.1 | 0.1 to 1.4 | 5, 14, 18 |
Eosinophils (x103/mm3) | 0.0 to 0.6 | 0.0 to 0.6 | 0.0 to 0.6 | 0.0 to 0.6 | 14, 18 |
Basophils (x103/mm3) | 0.0 to 0.2 | 0.0 to 0.1 | 0.0 to 0.1 | 0.0 to 0.1 | 14, 18 |
Transferrin (mg/dL) | 200 to 400 | 254 to 344 | 220 to 441 | 288 to 530 | 4, 5 |
Transferrin, saturation without iron (%) | 22 to 46¶ | Not reported | 10 to 44 | 5 to 37 | 3 |
Transferrin, saturation with iron (%) | 22 to 46¶ | Not reported | 18 to 92 | 9 to 98 | 3 |
Coagulation |
Antithrombin, functional (%) | 70 to 130 | 89 to 114 | 78 to 126 | 82 to 116 | 17, 19, 20 |
D to dimer (mcg/mL) | 0.22 to 0.74 | 0.05 to 0.95 | 0.32 to 1.29 | 0.13 to 1.70 | 17, 20 to 24, 30 |
Factor V (%) | 50 to 150 | 75 to 95 | 72 to 96 | 60 to 88 | 25 |
Factor VII (%) | 50 to 150 | 100 to 146 | 95 to 153 | 149 to 211 | 17 |
Factor VIII (%) | 50 to 150 | 90 to 210 | 97 to 312 | 143 to 353 | 17, 25 |
Factor IX (%) | 50 to 150 | 103 to 172 | 154 to 217 | 164 to 235 | 17 |
Factor XI (%) | 50 to 150 | 80 to 127 | 82 to 144 | 65 to 123 | 17 |
Factor XII (%) | 50 to 150 | 78 to 124 | 90 to 151 | 129 to 194 | 17 |
Fibrinogen (mg/dL) | 211 to 496 | 244 to 510 | 291 to 538 | 301 to 696 | 5, 17, 20, 21, 23, 24, 30 |
Homocysteine (mmol/L) | 4.4 to 10.8 | 3.34 to 11.00 | 2.0 to 26.9 | 3.2 to 21.4 | 6, 9, 10 to 12 |
International normalized ratio | 0.90 to 1.04◊ | 0.86 to 1.08 | 0.83 to 1.02 | 0.80 to 1.09 | 19, 24 |
Partial thromboplastin time, activated (seconds) | 26.3 to 39.4 | 23.0 to 38.9 | 22.9 to 38.1 | 22.6 to 35.0 | 5, 17, 19, 24 |
Plasminogen activator inhibitor to 1 (PAI to 1) antigen (pg/mL) | 17.3 ± 5.7 | 17.7 ± 1.9 | Not reported | 66.4 ± 4.9 | 30 |
Plasminogen activator inhibitor to 1 (PAI to 1) activity (arbitrary units) | 9.3 ± 1.9 | 9.0 ± 0.8 | Not reported | 31.4 ± 3.0 | 30 |
Prothrombin time (seconds) | 12.7 to 15.4 | 9.7 to 13.5 | 9.5 to 13.4 | 9.6 to 12.9 | 5, 17, 24 |
Protein C, functional (%) | 70 to 130 | 78 to 121 | 83 to 133 | 67 to 135 | 19, 25, 26 |
Protein S, total (%) | 70 to 140 | 39 to 105 | 27 to 101 | 33 to 101 | 17, 25, 26 |
Protein S, free (%) | 70 to 140 | 34 to 133 | 19 to 113 | 20 to 65 | 25, 26 |
Protein S, functional activity (%) | 65 to 140 | 57 to 95 | 42 to 68 | 16 to 42 | 25 |
Tissue plasminogen activator (ng/mL) | 1.6 to 13.0§ | 1.8 to 6.0 | 2.36 to 6.60 | 3.34 to 9.20 | 17, 19, 30 |
Tissue plasminogen activator inhibitor-1 (ng/mL) | 4 to 43 | 16 to 33 | 36 to 55 | 67 to 92 | 17 |
von Willebrand measurements |
von Willebrand factor antigen (%) | 75 to 125 | 62 to 318 | 90 to 247 | 84 to 422 | 20, 27, 28 |
ADAMTS-13, von Willebrand cleaving protease | 40 to 170¥ | 40 to 160 | 22 to 135 | 38 to 105 | 20, 28 |