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Cardiovascular disease risk scores

Cardiovascular disease risk scores
Risk score (year) Variables included Key variables excluded Endpoint assessed
Framingham risk score (1998)
  • Age
  • Gender
  • Total or LDL cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Systolic blood pressure (mmHg)
  • Diabetes mellitus (yes or no)
  • Current smoking (yes or no)
  • Blood pressure treatment (yes or no)
  • Family history of CVD (yes or no)
  • CHD death
  • Nonfatal MI
  • Unstable angina
  • Stable angina
Adult Treatment Panel (ATP III) hard CHD risk score (2002)
  • Age
  • Gender
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Systolic blood pressure (mmHg)
  • Blood pressure treatment (yes or no)
  • Current smoking (yes or no)
  • Diabetes mellitus (yes or no)
  • Family history of CVD (yes or no)
  • CHD death
  • Nonfatal MI
SCORE CVD death risk score (2003)
  • Age
  • Gender
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Systolic blood pressure (mmHg)
  • Current smoking (yes or no)
  • Region of Europe (high risk or low risk region)
  • Blood pressure treatment (yes or no)
  • Diabetes mellitus (yes or no)
  • Family history of CVD (yes or no)
  • CVD death (including CHD, arrhythmia, heart failure, stroke, aortic aneurysm, and peripheral vascular disease)
QRISK and QRISK2 risk calculators (2007)
  • Age
  • Gender
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Systolic blood pressure (mmHg)
  • Blood pressure treatment (yes or no)
  • Current smoking (yes or no)
  • Family history of CVD in first degree relative aged <60 years (yes or no)
  • Region of United Kingdom (score based on levels of unemployment, overcrowding, car ownership, home ownership)
  • Body mass index (kg/m2)
  • Diabetes mellitus (yes or no)
  • CHD death
  • Nonfatal MI
  • Coronary insufficiency or angina
  • Coronary revascularization
  • Fatal or nonfatal stroke
  • Transient ischemic attack
  • Intermittent claudication
Reynolds CVD risk score (2007/2008)
  • Age
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Systolic blood pressure (mmHg)
  • Diabetes mellitus assessed by hemoglobin A1c (percent)*
  • Current smoking (yes or no)
  • Parental history of MI before age 60 years (yes or no)
  • Serum hs-CRP (mg/L)
  • Diabetes mellitus (yes or no)*
  • Blood pressure treatment (yes or no)
  • Cardiovascular death
  • Nonfatal MI
  • Nonfatal stroke
  • Coronary revascularization
Framingham general CVD risk score (2008)
  • Age
  • Gender
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Systolic blood pressure (mmHg)
  • Blood pressure treatment (yes or no)
  • Diabetes mellitus (yes or no)
  • Current smoking (yes or no)
  • Family history of CVD (yes or no)
  • CHD death
  • Nonfatal MI
  • Coronary insufficiency or angina
  • Fatal or nonfatal ischemic or hemorrhagic stroke
  • Transient ischemic attack
  • Intermittent claudication
  • Heart failure
ACC/AHA pooled cohort hard CVD risk calculator (2013)
  • Age (validated only in patients 40 to 79 years of age)
  • Gender
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Systolic blood pressure (mmHg)
  • Blood pressure treatment (yes or no)
  • Diabetes mellitus (yes or no)
  • Current smoking (yes or no)
  • Family history of CVD (yes or no)
  • CHD death
  • Nonfatal MI
  • Fatal stroke
  • Nonfatal stroke
JBS3 risk score (2014)
  • Age
  • Gender
  • Ethnicity
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Systolic blood pressure (mmHg)
  • Blood pressure treatment (yes or no)
  • Diabetes mellitus (yes or no)
  • Current smoking (yes or no)
  • Family history of CVD in first degree relative aged <60 years (yes or no)
  • Chronic kidney disease
  • Atrial fibrillation
  • Rheumatoid arthritis
  • Region of United Kingdom (score based on levels of unemployment, overcrowding, car ownership, home ownership)
  • Body mass index (kg/m2)
  • None
  • CHD death
  • Nonfatal MI
  • Coronary insufficiency or angina
  • Coronary revascularization
  • Fatal or nonfatal stroke
  • Transient ischemic attack
  • Intermittent claudication
MESA risk score (2015)
  • Age
  • Gender
  • Ethnicity (non-Hispanic White people, Chinese American people, African American people, Hispanic people)
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Lipid lowering treatment (yes or no)
  • Systolic blood pressure (mmHg)
  • Blood pressure treatment (yes or no)
  • Diabetes mellitus (yes or no)
  • Current smoking (yes or no)
  • Family history of MI at any age (yes or no)
  • Coronary artery calcium score
  • Family history of CVD other than MI
  • CHD death
  • Nonfatal MI
  • Resuscitated cardiac arrest
  • Coronary revascularization in patient with angina
China-PAR risk predictor (2016)
  • Age
  • Gender
  • Total cholesterol (mg/dL)
  • HDL cholesterol (mg/dL)
  • Lipid lowering treatment (yes or no)
  • Systolic blood pressure (mmHg)
  • Blood pressure treatment (yes or no)
  • Diabetes mellitus (yes or no)
  • Current smoking (yes or no)
  • Waist circumference (cm)
  • Geographic region (northern or southern China)
  • Urbanization (yes or no, only in males)
  • Family history of ASCVD (yes or no, only in males)
  • None
  • CHD death
  • Nonfatal MI
  • Fatal or nonfatal stroke
LDL: low density lipoprotein; HDL: high density lipoprotein; CVD: cardiovascular disease; CHD: coronary heart disease; MI: myocardial infarction; hs-CRP: high sensitivity C-reactive protein; ASCVD: atherosclerotic cardiovascular disease.
* Diabetes mellitus, as assessed by hemoglobin A1c, was included in the Reynolds risk score for women but NOT included for men.
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