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Soft tissue lesions of the oral cavity in children

Soft tissue lesions of the oral cavity in children
Lesion Clinical features Management
Lesions of the gums
Eruption cyst/hematoma
  • Normal finding
  • Dome-shaped cyst
  • Associated with eruption of teeth
  • Cyst fluid may be mixed with blood (eruption hematoma)
  • No treatment necessary
Gingival pigmentation
  • Normal finding in dark-skinned children
  • No treatment necessary
Retrocuspid papillae
  • Firm, round, pink to red papule
  • 2 to 3 mm (0.1 inches) in diameter
  • Located on the inner gum below the lower canines
  • Often bilateral
  • Resolves spontaneously
Parulis ("gum boil")
  • Associated with primary tooth abscess
  • Soft, solitary, reddish papule on the outer gum above or below the abscessed tooth
  • Drainage or pus may be observed
  • Complete pulpectomy or extraction of involved tooth
Gingival overgrowth
  • Inflammatory
  • Associated with longstanding gingivitis or chronic mouth breathing
  • Erythematous gums with shiny, friable surface that bleeds easily
  • Involves the gums between the teeth and at the margins of the teeth
  • Often resolves with adequate plaque control
  • May require gingivectomy
  • Infiltrative
  • Associated with leukemia, particularly AML
  • Edematous and hemorrhagic
  • Treatment of underlying disease
  • Drug-induced
  • Commonly precipitated by phenytoin, nifedipine, and cyclosporine A
  • Painless, firm, fibrous overgrowth
  • Bleeding is uncommon
  • May progress to cover the crown of the tooth
  • Meticulous oral hygiene
  • Discontinuation of offending drug, if possible
  • May require gingivectomy
  • Hereditary
  • Onset in early childhood
  • Progressive nonhemorrhagic fibrous enlargement
  • May be associated with failure or delay of primary or permanent tooth eruption
  • Meticulous oral hygiene
  • Gingivectomy
  • Vascular (localized juvenile spongiotic gingival hyperplasia)
  • Localized erythema of the attached gingiva of the front teeth
  • Most common in female adolescents
  • Topical corticosteroids
Gingival recession
  • Associated with abnormally erupted teeth
  • Narrowing of the gums above and below the teeth
  • Orthodontic repositioning of malpositioned teeth
  • Gingival grafting may be necessary for severe recession
HIV gingivitis (linear gingival erythema)
  • Brightly inflamed gums at the margins of the teeth
  • Bleeds easily
  • Painful
  • Debridement
  • Antibiotics
  • Antibacterial oral rinses
Other gum lesions:
  • Hemangiomas
  • Irritant fibromas
  • Peripheral ossifying fibromas
  • Pyogenic granulomas
  • Peripheral giant cell granulomas
  • Traumatic ulcers
  • Aphthous ulcers
  • HSV gingivostomatitis
Clinical features and management of these lesions are described in the section on "Lesions that occur at multiple sites"
Lesions of the tongue
Ankyloglossia
  • Tongue movement is restricted by a short, tight frenum between the tongue and floor of the mouth
  • May require frenotomy (refer to UpToDate content on ankyloglossia in children)
Congenital melanotic macules
  • Present from birth
  • Single or multiple, asymptomatic, hyperpigmented macules
  • Range from 3 mm to 3 cm (0.1 to 1.2 inches) in diameter; size increases proportionally as the child grows
  • No family history of systemic conditions associated with mucosal pigmentation (eg, Peutz-Jeghers syndrome)
  • Monitor over time
Geographic tongue
  • Pink to red, slightly depressed lesions with irregular, elevated, curvilinear white or yellow borders
  • Pattern of lesions changes continuously
  • Does not require treatment
  • Avoidance of acidic foods and beverages is helpful if the lesions are sensitive
Fissured tongue
  • Marked central fissure from front to back of tongue
  • Smaller fissures radiate laterally from the central fissure
  • Removal of trapped food particles through brushing of the tongue
Mucoceles Clinical feature and management of mucoceles are described in the section on "Lesions of the lips"
Other tongue lesions:
  • Hemangiomas
  • Lymphangiomas
  • Irritation fibromas 
  • Traumatic ulcers
  • Aphthous ulcers
  • Thrush
  • HSV gingivostomatitis
  • HFMD
Clinical features and management of these lesions are described in the section on "Lesions that occur at multiple sites"
Lesions of the lips
Herpes labialis (fever blister, cold sore)
  • Vesicular eruption of skin adjacent to lip
  • Vesicles rupture to form ulcers and crusts
  • Caused by HSV
  • Refer to UpToDate content on treatment of HSV type 1 infection for treatment indications and options
Angular cheilitis (perlèche)
  • Painful fissuring at the corners of the mouth
  • Usually caused by Candida albicans
  • Maintain oral hygiene
  • Apply barrier cream or petrolatum
  • May require antifungal therapy (refer to UpToDate content on angular cheilitis)
Abnormalities of the labial frena
  • Persistence of raphe between the upper labial frenum and the palatal papilla
  • May lead to widely spaced front teeth (diastema)
  • Diastema may require orthodontic treatment
  • May require frenotomy
  • Extension of frenum to central incisors
  • May lead to gingival recession and bone loss
  • May require frenotomy to prevent bone loss
  • Absence or hypoplasia
  • May be associated with Ehlers-Danlos syndrome
  • May be associated with infantile hypertrophic pyloric stenosis
  • No treatment required
  • Monitor for signs and symptoms of Ehlers-Danlos syndrome and infantile hypertrophic pyloric stenosis
Mucoceles and ranulas
  • Painless swelling, smooth walled, bluish or translucent
  • Usually <1 cm (0.4 inches) in diameter
  • Usually located on the inside of the lower lip but may occur on the tongue or floor of the mouth (ranula)
  • May spontaneously resolve
  • Surgical excision with associated minor salivary gland for mucoceles that interfere with function or cause discomfort
  • Surgical treatment, ranging from incision and drainage to marsupialization to excision for ranulas 
Other lip lesions:
  • Hemangiomas
  • Lymphangiomas
  • Irritation fibromas
  • Pyogenic granulomas
  • Traumatic ulcers
  • Aphthous ulcers
  • Thrush
  • HSV gingivostomatitis
  • HFMD
Clinical features and management of these lesions are described in the section on "Lesions that occur at multiple sites"
Lesions of the palate
Herpangina
  • Lesions progress from yellow/greyish-white papules to vesicles to shallow ulcerations
  • The lesions most frequently involve the soft palate, tonsils, and uvula
  • Typically occurs in children age 3 to 10 years
  • Supportive care to prevent dehydration
  • Symptomatic treatment of pain
Other palatal lesions:
  • Irritation fibromas
  • Traumatic ulcers
  • Aphthous ulcers
  • Thrush
  • HSV gingivostomatitis
  • HFMD
Clinical features and management of these lesions are described in the section on "Lesions that occur at multiple sites"
Lesions of the buccal mucosa
  • Hemangiomas
  • Lymphangiomas
  • Irritation fibromas
  • Aphthous ulcers
  • Traumatic ulcers
  • Thrush
  • HSV gingivostomatitis
  • HFMD
Clinical features and management of these lesions are described in the section on "Lesions that occur at multiple sites"
Lesions that occur at multiple sites
Hemangioma
  • Red or bluish-red, raised, moderately firm to palpation
  • Appear early in life, enlarge during infancy, and regress during childhood
  • May occur on any oral mucosa (eg, gums, tongue, lips, palate, buccal mucosa)
  • Refer to UpToDate content on management of infantile hemangiomas
Lymphangiomas
  • Pink to reddish-blue, soft, compressible
  • May be present at birth or develop early in life
  • May occur on the tongue, lips, or buccal mucosa
  • May require surgical resection or percutaneous chemoablation
Irritation fibroma
  • Pale, pink, smooth, firm, <1 cm (0.4 inches) in diameter, sessile or pedunculated base
  • Usually occur on the tongue, lip, palate, or buccal mucosa, but may occur on any mucosal surface
  • Surgical excision if it interferes with function
Peripheral ossifying fibroma
  • Traumatic overgrowth that contains mineralized tissues (eg, bone, calcifications)
  • Predominantly occurs on the gingiva
  • Surgical excision down to the bone
Pyogenic granuloma (lobular capillary hemangioma)
  • Bright red lesion with rapid growth, friable surface, easy bleeding 
  • May be triggered by trauma
  • More common in females
  • Surgical excision
Peripheral giant cell granuloma
  • Bluish-purple traumatic overgrowth
  • Typically occur on the gingiva
  • Slightly more common on the lower gums
  • More common in children with mixed dentition and adults between 30 and 40 years of age
  • More common in females
  • Surgical excision
Traumatic ulcers
  • Occur on the gums, tongue, lips, palate, and buccal mucosa
  • Spontaneous healing with removal of source of trauma
Aphthous ulcer
  • Localized, shallow, round to oval ulcers with grayish base
  • Occur on the gums, tongue, lips, palate, and buccal mucosa
  • Refer to UpToDate content on aphthous ulcerations
Thrush
  • White plaques on the tongue, lips, palate, and/or buccal mucosa
  • Sterilization/decolonization of items placed in the mouth (eg, pacifiers, bottle nipples)
  • Topical or systemic antifungal therapy may be warranted for symptomatic patients
  • Refer to UpToDate content on oropharyngeal candidiasis in children
HSV gingivostomatitis
  • Red, edematous marginal gingivae
  • Clusters of small vesicles that become yellow after rupture and are surrounded by a red halo
  • Vesicles occur on the gums, tongue, lips, hard palate, buccal mucosa, and perioral skin
  • Supportive care to prevent dehydration
  • Symptomatic pain control
  • Topical barrier cream
  • Oral acyclovir may be warranted (refer to UpToDate content on herpetic gingivostomatitis in young children)
HFMD
  • Oral vesicles, small cutaneous lesions on the hands, feet, buttocks, and genitalia
  • Supportive care to prevent dehydration
  • Symptomatic pain control
AML: acute myeloid leukemia; HIV: human immunodeficiency virus; HSV: herpes simplex virus; HFMD: hand, foot, and mouth disease.
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