Introduction — This topic includes links to society and government-sponsored guidelines from selected countries and regions around the world. We will update these links periodically; newer versions of some guidelines may be available on each society's website. Some societies may require users to log in to access their guidelines.
The recommendations in the following guidelines may vary from those that appear in UpToDate topic reviews. Readers who are looking for UpToDate topic reviews should use the UpToDate search box to find the relevant content.
Links to related guidelines are provided separately. (See "Society guideline links: Parasomnias, hypersomnias, and circadian rhythm disorders".)
International
●International Restless Legs Syndrome Study Group (IRLSSG): Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children (2018)
●IRLSSG, European Restless Legs Syndrome Study Group (EURLSSG), and Restless Legs Syndrome Foundation (RLS-F): Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention, and treatment of dopaminergic augmentation (2016)
●IRLSSG: Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation (2015)
●IRLSSG: Consensus on restless legs syndrome/Willis-Ekbom disease diagnostic criteria – History, rationale, description, and significance, update (2014)
●IRLSSG: The long-term treatment of restless legs syndrome/Willis-Ekbom disease – Evidence-based guidelines and clinical consensus best practice guidance (2013)
●IRLSSG: Pediatric restless legs syndrome diagnostic criteria, update (2013)
United States
●Choosing Wisely: Don't use polysomnography to diagnose restless legs syndrome (2014, updated 2021)
●Restless Legs Syndrome (RLS) Foundation: An updated algorithm for the management of restless legs syndrome (2021)
●American Academy of Neurology (AAN): Practice guideline summary for the treatment of restless legs syndrome in adults (2016, reaffirmed 2019)
●RLS Foundation: Consensus recommendations for the appropriate use of opioids in the treatment of refractory restless legs syndrome (2018)
●International Restless Legs Syndrome Study Group (IRLSSG), European Restless Legs Syndrome Study Group (EURLSSG), and Restless Legs Syndrome Foundation (RLS-F): Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention, and treatment of dopaminergic augmentation (2016)
●American Academy of Sleep Medicine (AASM): Clinical practice guideline for the treatment of restless legs syndrome and periodic limb movement disorder in adults – Practice parameters with an evidence-based systematic review and meta-analyses, update (2012)
Europe
●International Restless Legs Syndrome Study Group (IRLSSG), European Restless Legs Syndrome Study Group (EURLSSG), and Restless Legs Syndrome Foundation (RLS-F): Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention, and treatment of dopaminergic augmentation (2016)
●European Federation of Neurological Societies (EFNS), European Neurological Society (ENS), and European Sleep Research Society (ESRS): European guidelines on management of restless legs syndrome (2012)
