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Percentage of HDL cholesterol synthesized by the liver, intestine, and peripheral cells

Percentage of HDL cholesterol synthesized by the liver, intestine, and peripheral cells
ABCA1 = ATP-binding cassette transporter A1; HDL: high-density lipoprotein; CE: cholesterol efflux; SR-BI: scavenger receptor class B type I; ABCG1 = ATP-binding cassette transporter G1.
Data from:
  1. Haghpassand M, Bourassa PA, Francone OL, Aiello RJ. Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels. J Clin Invest 2001; 108:1315.
  2. Vaisman BL, Lambert G, Amar M, et al. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J Clin Invest 2001; 108:303.
  3. Wellington CL, Brunham LR, Zhou S, et al. Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1. J Lipid Res 2003; 44:1470.
  4. Timmins JM, Lee JY, Boudyguina E, et al. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest 2005; 115:1333.
Modified from: Rosenson RS, Brewer HB, Davidson WS, et al. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation 2012; 125:1905.
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