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Ischemic heart disease-based prediction algorithms

	Study group (diagnostic criteria for entry)
	TIMI (unstable angina)	GRACE (post-STEMI or NSTEMI ACS)	HEART (ED observation unit evaluation)	DAPT (PCI patients)	ACTION (hospitalized MI)
Year of publication	2000	2004	2015	2016	2016
Age	X	X	X	X	X
Traditional CV factors (various)	X		X	X	X
ECG ST-segment elevation	X	X	X		X
2+ ischemic episodes past 24 hours	X			X
Strong history of ischemic symptoms			X	X
Troponin levels	X (older assay)	X (older assay)	X (newer assay)		X (newer assay)
Nontroponin CV biomarkers	X	Serum creatinine		Renal function	eGFR
Heart rate		X			X
Heart failure		X		X	At presentation
History of stroke or PAD				X
Cardiac arrest					At presentation
Cardiogenic shock					At presentation
Stent information				X
Validation	Multiple	Multiple	External	Internal	Internal

X denotes that the information was used for that scoring system.

ACS: acute coronary syndrome; ACTION: Acute Coronary Treatment and Intervention Outcomes Network; CV: cardiovascular; DAPT: Dual Antiplatelet Therapy; ED: emergency department; eGFR: estimated glomerular filtration rate; GRACE: Global Registry of Acute Coronary Events; HEART: History, ECG, Age, Risk factor, Troponin; MI: myocardial infarction; NSTEMI: non-ST elevation myocardial infarction; PAD: peripheral arterial disease; PCI: percutaneous coronary intervention; STEMI: ST-segment elevation myocardial infarction; TIMI: Thrombolysis In Myocardial Infarction.

From: Wilson PWF, D'Agostino RB. No one size fits all: Scoring risk of in-hospital death after myocardial infarction. J Am Coll Cardiol 2016; 68:636. Table used with the permission of Elsevier Inc. All rights reserved.

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