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Considerations regarding melatonin receptor agonist* for sleep in children

Considerations regarding melatonin receptor agonist* for sleep in children
Pros Cons
  • Decreases circadian-mediated arousal at bedtime, not sedating
  • Minimal changes in sleep architecture
  • Little interaction with other neurotransmitters
  • More consistent preparation
  • No evidence of residual daytime effects
  • Classified by the FDA as a hypnotic (non-schedule IV); no limitations on duration of use, no abuse potential
  • Treatment of sleep-onset insomnia only
  • Moderate efficacy; objective (PSG-documented) improvements are more prominent than subjective (patient-perceived) improvements 
  • Side effects:
    • Dizziness, fatigue
    • Increased prolactin or decreased testosterone reported
  • Avoid co-administration with fluvoxamine
  • Cost; lack of insurance coverage
Bottom line – May be a reasonable choice for mild sleep-onset insomnia, especially with circadian component, but cost and lack of insurance coverage limits use.
FDA: US Food and Drug Administration; PSG: polysomnography.
* Ramelteon (Rozerem).
Courtesy of Judith A Owens, MD, MPH.
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