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Disease-specific criteria for estimating 6-month prognosis, and hospice eligibility, in HIV disease

Disease-specific criteria for estimating 6-month prognosis, and hospice eligibility, in HIV disease
HIV disease
Patients will be considered to be in the terminal stage of their illness (life expectancy of 6 months or less) if they meet the following criteria (1 and 2 should be present; factors from 3 will add supporting documentation):
  1. CD4 count <25 cells per microliter or persistent (2 or more assays at least 1 month apart) viral load >100,000 copies/mL, plus one of the following:
  • CNS lymphoma, untreated or persistent despite treatment
  • Wasting (loss of at least 10% lean body mass)
  • MAC bacteremia, untreated, unresponsive to treatment, or treatment refused
  • Progressive multifocal leukoencephalopathy
  • Systemic lymphoma, with advanced HIV disease and partial response to chemotherapy
  • Visceral Kaposi sarcoma, unresponsive to therapy
  • Renal failure in the absence of dialysis
  • Cryptosporidium infection
  • Toxoplasmosis, unresponsive to therapy
  1. Decreased performance status, as measured by the Karnofsky Performance Status (KPS) scale, ≤50%.
  1. Documentation of the following factors will support eligibility for hospice care:
  • Chronic persistent diarrhea for 1 year
  • Persistent serum albumin <2.5 g/dL
  • Concomitant, active substance abuse
  • Age >50 years
  • Absence of or resistance to effective antiretroviral, chemotherapeutic, and prophylactic drug therapy related specifically to HIV disease
  • Advanced AIDS dementia complex
  • Toxoplasmosis
  • Congestive heart failure, symptomatic at rest
  • Advanced liver disease
Karnofsky = 50: Requires considerable assistance and frequent medical care.
Karnofsky <50: Unable to care for self; requires equivalent of institutional or hospital care; disease may be progressing rapidly.
HIV: human immunodeficiency virus; CNS: central nervous system; MAC: mycobacterium avium complex; AIDS: acquired immunodeficiency syndrome.
Sources:
  1. The NHO medical guidelines for non-cancer disease and local medical review policy: hospice access for patients with diseases other than cancer. Hosp J 1999.
  2. Centers for Medicare & Medicaid Services. Local Coverage Determination (LCD) for Hospice Determining Terminal Status (L33393). (Accessed on January 18, 2016).
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