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Neuroendocrine tumors of the pancreas TNM staging AJCC UICC 8th edition

Neuroendocrine tumors of the pancreas TNM staging AJCC UICC 8th edition
Primary tumor (T)
T category T criteria
TX Tumor cannot be assessed
T1 Tumor limited to the pancreas,* <2 cm
T2 Tumor limited to the pancreas,* 2 to 4 cm
T3 Tumor limited to the pancreas,* >4 cm; or tumor invading the duodenum or common bile duct
T4 Tumor invading adjacent organs (stomach, spleen, colon, adrenal gland) or the wall of large vessels (celiac axis or the superior mesenteric artery)
* Limited to the pancreas means there is no invasion of adjacent organs (stomach, spleen, colon, adrenal gland) or the wall of large vessels (celiac axis or the superior mesenteric artery). Extension of tumor into peripancreatic adipose tissue is NOT a basis for staging.
NOTE: Multiple tumors should be designated as such (the largest tumor should be used to assign T category):
  • If the number of tumors is known, use T(#); eg, pT3(4) N0 M0.
  • If the number of tumors is unavailable or too numerous, use the m suffix, T(m); eg, pT3(m) N0 M0.
Regional lymph nodes (N)
N category N criteria
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node involvement
N1 Regional lymph node involvement
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastases
M1a Metastasis confined to liver
M1b Metastases in at least one extrahepatic site (eg, lung, ovary, nonregional lymph node, peritoneum, bone)
M1c Both hepatic and extrahepatic metastases
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
T1 N0 M0 I
T2 N0 M0 II
T3 N0 M0 II
T4 N0 M0 III
Any T N1 M0 III
Any T Any N M1 IV
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer control.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.
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