Primary tumor (T) |
T category | T criteria |
TX | Primary tumor cannot be assessed |
T0 | No evidence of primary tumor |
Tis | Carcinoma in situ/high-grade dysplasia |
T1 | Tumor confined to the bile duct, with extension up to the muscle layer or fibrous tissue |
T2 | Tumor invades beyond the wall of the bile duct to surrounding adipose tissue, or tumor invades adjacent hepatic parenchyma |
T2a | Tumor invades beyond the wall of the bile duct to surrounding adipose tissue |
T2b | Tumor invades adjacent hepatic parenchyma |
T3 | Tumor invades unilateral branches of the portal vein or hepatic artery |
T4 | Tumor invades the main portal vein or its branches bilaterally, or the common hepatic artery; or unilateral second-order biliary radicals with contralateral portal vein or hepatic artery involvement |
Regional lymph nodes (N) |
N category | N criteria |
NX | Regional lymph nodes cannot be assessed |
N0 | No regional lymph node metastasis |
N1 | One to three positive lymph nodes typically involving the hilar, cystic duct, common bile duct, hepatic artery, posterior pancreatoduodenal, and portal vein lymph nodes |
N2 | Four or more positive lymph nodes from the sites described for N1 |
Distant metastasis (M) |
M category | M criteria |
M0 | No distant metastasis |
M1 | Distant metastasis |
Prognostic stage groups |
When T is... | And N is... | And M is... | Then the stage group is... |
Tis | N0 | M0 | 0 |
T1 | N0 | M0 | I |
T2a-b | N0 | M0 | II |
T3 | N0 | M0 | IIIA |
T4 | N0 | M0 | IIIB |
Any T | N1 | M0 | IIIC |
Any T | N2 | M0 | IVA |
Any T | Any N | M1 | IVB |