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GIST TNM staging AJCC UICC 8th edition

Primary tumor (T)
T category	T criteria
TX	Primary tumor cannot be assessed
T0	No evidence of primary tumor
T1	Tumor 2 cm or less
T2	Tumor more than 2 cm but not more than 5 cm
T3	Tumor more than 5 cm but not more than 10 cm
T4	Tumor more than 10 cm in greatest dimension
Regional lymph nodes (N)
N category	N criteria
N0	No regional lymph node metastasis or unknown lymph node status
N1	Regional lymph node metastasis
Distant metastasis (M)
M category	M criteria
M0	No distant metastasis
M1	Distant metastasis
Mitotic rate
Mitotic rate	Definition
Low	Five or fewer mitoses per 5 mm²
High	Over five mitoses per 5 mm²
Prognostic stage groups
Gastric and omental GIST
When T is...	And N is...	And M is...	And mitotic rate is...	Then the stage group is...
T1 or T2	N0	M0	Low	IA
T3	N0	M0	Low	IB
T1	N0	M0	High	II
T2	N0	M0	High	II
T4	N0	M0	Low	II
T3	N0	M0	High	IIIA
T4	N0	M0	High	IIIB
Any T	N1	M0	Any rate	IV
Any T	Any N	M1	Any rate	IV
Small intestinal, esophageal, colorectal, mesenteric, and peritoneal GIST
When T is...	And N is...	And M is...	And mitotic rate is...	Then the stage group is...
T1 or T2	N0	M0	Low	I
T3	N0	M0	Low	II
T1	N0	M0	High	IIIA
T4	N0	M0	Low	IIIA
T2	N0	M0	High	IIIB
T3	N0	M0	High	IIIB
T4	N0	M0	High	IIIB
Any T	N1	M0	Any rate	IV
Any T	Any N	M1	Any rate	IV

GIST: gastrointestinal stromal tumor; TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.

Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.

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