Primary tumor (T) |
T category | T criteria |
TX | Primary tumor cannot be assessed |
T0 | No evidence of primary tumor |
T1 | Tumor size category 1 |
T1a | Tumor size category 1 without ciliary body involvement and extraocular extension |
T1b | Tumor size category 1 with ciliary body involvement |
T1c | Tumor size category 1 without ciliary body involvement but with extraocular extension ≤5 mm in largest diameter |
T1d | Tumor size category 1 with ciliary body involvement and extraocular extension ≤5 mm in largest diameter |
T2 | Tumor size category 2 |
T2a | Tumor size category 2 without ciliary body involvement and extraocular extension |
T2b | Tumor size category 2 with ciliary body involvement |
T2c | Tumor size category 2 without ciliary body involvement but with extraocular extension ≤5 mm in largest diameter |
T2d | Tumor size category 2 with ciliary body involvement and extraocular extension ≤5 mm in largest diameter |
T3 | Tumor size category 3 |
T3a | Tumor size category 3 without ciliary body involvement and extraocular extension |
T3b | Tumor size category 3 with ciliary body involvement |
T3c | Tumor size category 3 without ciliary body involvement but with extraocular extension ≤5 mm in largest diameter |
T3d | Tumor size category 3 with ciliary body involvement and extraocular extension ≤5 mm in largest diameter |
T4 | Tumor size category 4 |
T4a | Tumor size category 4 without ciliary body involvement and extraocular extension |
T4b | Tumor size category 4 with ciliary body involvement |
T4c | Tumor size category 4 without ciliary body involvement but with extraocular extension ≤5 mm in largest diameter |
T4d | Tumor size category 4 with ciliary body involvement and extraocular extension ≤5 mm in largest diameter |
T4e | Any tumor size category with extraocular extension >5 mm in largest diameter |
NOTES: - Primary ciliary body and choroidal melanomas are classified according to the four tumor size categories defined in figure entitled "Classification for ciliary body and choroid uveal melanoma based on thickness and diameter."
- In clinical practice, the largest tumor basal diameter may be estimated in optic disc diameters (DD; average: 1 DD = 1.5 mm), and tumor thickness may be estimated in diopters (average: 2.5 diopters = 1 mm). Ultrasonography and fundus photography are used to provide more accurate measurements.
- When histopathologic measurements are recorded after fixation, tumor diameter and thickness may be underestimated because of tissue shrinkage.
|
Classification for ciliary body and choroid uveal melanoma based on thickness and diameter |
| Largest basal diameter (mm) |
Thickness (mm) | ≤3.0 | 3.1 to 6.0 | 6.1 to 9.0 | 9.1 to 12.0 | 12.1 to 15.0 | 15.1 to 18.0 | >18.0 |
>15.0 | | | | | 4 | 4 | 4 |
12.1 to 15.0 | | | | 3 | 3 | 4 | 4 |
9.1 to 12.0 | | 3 | 3 | 3 | 3 | 3 | 4 |
6.1 to 9.0 | 2 | 2 | 2 | 2 | 3 | 3 | 4 |
3.1 to 6.0 | 1 | 1 | 1 | 2 | 2 | 3 | 4 |
≤3.0 | 1 | 1 | 1 | 1 | 2 | 2 | 4 |
|
Regional lymph nodes (N) |
N category | N criteria |
NX | Regional lymph nodes cannot be assessed |
N0 | No regional lymph node involvement |
N1 | Regional lymph node metastases or discrete tumor deposits in the orbit |
N1a | Metastasis in one or more regional lymph node(s) |
N1b | No regional lymph nodes are positive, but there are discrete tumor deposits in the orbit that are not contiguous to the eye (choroidal and ciliary body) |
Distant metastasis (M) |
M category | M criteria |
M0 | No distant metastasis by clinical classification |
M1 | Distant metastasis |
M1a | Largest diameter of the largest metastasis ≤3.0 cm |
M1b | Largest diameter of the largest metastasis 3.1-8.0 cm |
M1c | Largest diameter of the largest metastasis ≥8.1 cm |
Prognostic stage groups |
When T is... | And N is... | And M is... | Then the stage group is... |
T1a | N0 | M0 | I |
T1b-d | N0 | M0 | IIA |
T2a | N0 | M0 | IIA |
T2b | N0 | M0 | IIB |
T3a | N0 | M0 | IIB |
T2c-d | N0 | M0 | IIIA |
T3b-c | N0 | M0 | IIIA |
T4a | N0 | M0 | IIIA |
T3d | N0 | M0 | IIIB |
T4b-c | N0 | M0 | IIIB |
T4d-e | N0 | M0 | IIIC |
Any T | N1 | M0 | IV |
Any T | Any N | M1a-c | IV |