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HPV-related oropharyngeal carcinoma TNM clinical staging AJCC UICC 8th edition

HPV-related oropharyngeal carcinoma TNM clinical staging AJCC UICC 8th edition
Primary tumor (T)
T category T criteria
T0 No primary identified
T1 Tumor 2 cm or smaller in greatest dimension
T2 Tumor larger than 2 cm but not larger than 4 cm in greatest dimension
T3 Tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis
T4 Moderately advanced local disease.
Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible or beyond.*
* Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of the larynx.
Regional lymph nodes (N) - Clinical N (cN)
N category N criteria
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 One or more ipsilateral lymph nodes, none larger than 6 cm
N2 Contralateral or bilateral lymph nodes, none larger than 6 cm
N3 Lymph node(s) larger than 6 cm
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastasis
Prognostic stage groups - Clinical
When T is... And N is... And M is... Then the stage group is...
T0, T1, or T2 N0 or N1 M0 I
T0, T1, or T2 N2 M0 II
T3 N0, N1, or N2 M0 II
T0, T1, T2, T3, or T4 N3 M0 III
T4 N0, N1, N2, or N3 M0 III
Any T Any N M1 IV
HPV: human papillomavirus; TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing.
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