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Hepatitis A vaccination: Dosing and schedule

Hepatitis A vaccination: Dosing and schedule
Vaccine Trade name Age group (years) Dosage Route Schedule Booster
Hepatitis A vaccine, inactivated Havrix 1 to 18 0.5 mL (720 ELU) IM 0, 6 to 12 months None
≥19 1 mL (1440 ELU) IM 0, 6 to 12 months None
Hepatitis A vaccine, inactivated Vaqta 1 to 18 0.5 mL (25 U) IM 0, 6 to 18 months None
≥19 1 mL (50 U) IM 0, 6 to 18 months None
Combined hepatitis A and B vaccine* Twinrix ≥18 (primary) 1 mL (720 ELU HAV + 20 mcg HBsAg) IM 0, 1, 6 months None
≥18 (accelerated) 1 mL (720 ELU HAV + 20 mcg HBsAg) IM 0, 7, 21 to 30 days 12 months
HAV: hepatitis A virus; ELU: enzyme-linked immunosorbent assay units of inactivated HAV; IM: intramuscular; U: units of HAV antigen; HBsAg: hepatitis B surface antigen.
* Combined hepatitis A and B vaccine (Twinrix) should not be used for postexposure prophylaxis.
Reproduced from: Nelson NP, Link-Gelles R, Hofmeister MG, et al. Update: Recommendations of the Advisory Committee on Immunization Practices for use of hepatitis A vaccine for postexposure prophylaxis and for preexposure prophylaxis for international travel. MMWR Morb Mortal Wkly Rep 2018; 67:1216.
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