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Uptodate Reference Title
Anatomy of the voltage-gated sodium channel
Anatomy of the voltage-gated sodium channel
The sodium channel alpha (D1-D4) and beta (β) subunits are transmembrane proteins. The four homologous domains of the alpha subunit (D1-D4) are represented in different colors. The transmembrane segments associate in the membrane to form a sodium-permeable pore lined by the re-entrant S5–S6 pore-loop segments (inset).
Republished with permission of the American Society for Clinical Investigation, from Meisler MH, Kearney JA. Sodium channel mutations in epilepsy and other neurological disorders. J Clin Invest 2005; 115:2011; permission conveyed through Copyright Clearance Center, Inc.