Intracranial calcifications in congenital Zika virus infection

Neuroimaging with CT and MRI showing intracranial calcifications in infants with CZS.
(Panels A and B) Axial (A) and coronal (B) noncontrast CT images showing punctate subcortical hyperdense (bright) lesions (arrows), consistent with calcification.
(Panel C) Axial T2-weighted MRI showing multiple punctate hypointense (dark) lesions in the basal ganglia bilaterally (dashed circles), consistent with calcification.

CT: computed tomography; MRI: magnetic resonance imaging; CZS: congenital Zika syndrome.

From: Pool KL, Adachi K, Karnezis S, et al. Association between neonatal neuroimaging and clinical outcomes in Zika-exposed infants from Rio de Janeiro, Brazil. JAMA Netw Open 2019; 2:e198124. Available at: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2740070. Copyright © 2019 The Authors. Reproduced under the terms of the Creative Commons CC-BY License.

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