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Monitoring of patients receiving interferon therapy for the treatment of HBV

Assessment point	Laboratory tests
Baseline	CBC with differential Hepatic panel* HBV DNA HBeAg and anti-HBe^¶ HBsAg Quantitative HBsAg^Δ INR TSH Creatinine Triglycerides Glucose Pregnancy test^◊
Week 4	CBC with differential Hepatic panel*
Week 12	CBC with differential Hepatic panel* HBV DNA Quantitative HBsAg^Δ TSH Pregnancy test^◊
Week 24	CBC with differential Hepatic panel* HBV DNA HBeAg and anti-HBe^¶ TSH Pregnancy test^◊
Week 48	CBC with differential Hepatic panel* HBV DNA HBeAg and anti-HBe^¶ HBsAg^§ TSH Pregnancy test^◊
Week 12 post-treatment	CBC with differential Hepatic panel* HBV DNA HBeAg and anti-HBe^¶ TSH
Week 24 post-treatment	CBC with differential Hepatic panel* HBV DNA HBeAg and anti-HBe^¶ HBsAg^§
Week 36 post-treatment	CBC with differential Hepatic panel* HBV DNA HBeAg and anti-HBe^¶ HBsAg^§
Week 48 post-treatment	CBC with differential Hepatic panel* HBV DNA HBeAg and anti-HBe^¶ HBsAg^§

ALT: alanine aminotransferase; AST: aspartate aminotransferase; anti-HBe: hepatitis B e antibody; CBC: complete blood count; HBeAg: hepatitis B e antigen; HBsAg: hepatitis B surface antigen; HBV: hepatitis B virus; INR: international normalized ratio; TSH: thyroid stimulating hormone.
* Hepatic panel includes: ALT, AST, albumin, bilirubin, and alkaline phosphatase.
¶ Only for patients who are HBeAg-positive at baseline.
Δ If available to assess utility of continued therapy.
◊ Only for women of childbearing age.
§ Only for HBeAg-negative patients if HBV DNA is undetectable and for HBeAg-positive patients who have undergone HBeAg seroconversion.

Adapted from: Konerman MA, Lok AS. Interferon treatment for hepatitis B. Clin Liver Dis 2016 (in press).

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