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Calculator: FIB-4 index, an indirect marker for liver fibrosis in adults (conventional units)*

Calculator: FIB-4 index, an indirect marker for liver fibrosis in adults (conventional units)*

Age   yr
AST   Units/L
ALT   Units/L

Important: Inputs must be complete to perform calculation.

FIB-4   Points
Decimal precision  



FIB-4 interpretation

Points <1.45: Cirrhosis less likely
Points ≥1.45 and ≤3.25: Indeterminate
Points >3.25: Cirrhosis more likely


  • FIB-4: Fibrosis-4; ALT: alanine aminotransferase; AST: aspartate aminotransferase.
  • The normal reference range for Platelets is approximately 150000 to 400000/microL (conventional units) [150 to 400 X 109/L (SI units)].
  • The FIB-4 index diagnostic cutoffs produce a negative predictive value of 94.7% with sensitivity 73.4% and a positive predictive value of 82.1% with a specificity of 98.2%.
  • * This calculator uses conventional units (also known as US units and gravimetric units) as the default for inputs. Do not use this calculator if you are using SI units (Système international d'unités); please refer instead to the SI units version of this calculator.

Equations used
FIB-4 = Age * AST / (0.001 * Platelets * sqr(ALT))


Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

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