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Calculator: FIB-4 index, an indirect marker for liver fibrosis in adults (conventional units)*


Calculator: FIB-4 index, an indirect marker for liver fibrosis in adults (conventional units)*

 
Input
 
Age   yr
Platelets  
AST   Units/L
ALT   Units/L

 
Result
 
Important: Inputs must be complete to perform calculation.

 
 
FIB-4   Points
 
Decimal precision  

 

 

FIB-4 interpretation

 
Points <1.45: Cirrhosis less likely
Points ≥1.45 and ≤3.25: Indeterminate
Points >3.25: Cirrhosis more likely

 
 

 
Notes
  • FIB-4: Fibrosis-4; ALT: alanine aminotransferase; AST: aspartate aminotransferase.
  • The normal reference range for Platelets is approximately 150000 to 400000/microL (conventional units) [150 to 400 X 109/L (SI units)].
  • The FIB-4 index diagnostic cutoffs produce a negative predictive value of 94.7% with sensitivity 73.4% and a positive predictive value of 82.1% with a specificity of 98.2%.
  • * This calculator uses conventional units (also known as US units and gravimetric units) as the default for inputs. Do not use this calculator if you are using SI units (Système international d'unités); please refer instead to the SI units version of this calculator.

 
Equations used
 
FIB-4 = Age * AST / (0.001 * Platelets * sqr(ALT))

 

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

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