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UpToDate recommendations for pneumococcal vaccination in recipients of previous pneumococcal vaccines

The ACIP updated its pneumococcal vaccine recommendations in 2022. This algorithm provides guidance to clinicians for adults who have already initiated or completed a primary pneumococcal vaccine series with older pneumococcal vaccine formulations. Refer to the UpToDate text on pneumococcal vaccination in adults for additional information.

PCV20: 20-valent pneumococcal conjugate vaccine; PPSV23: 23-valent pneumococcal polysaccharide vaccine; PCV13: 13-valent pneumococcal conjugate vaccine; ACIP: United States Centers for Disease Control and Preventions Advisory Committee on Immunization Practices; PCV15: 15-valent pneumococcal conjugate vaccine.

* If PCV20 is not available, PCV15 is a recommended alternative.

¶ Some experts favor revaccination with PPSV23 for select individuals. Refer to the UpToDate text on pneumococcal vaccination in adults for additional information.

Δ In high-risk individuals (eg, immunocompromising conditions, cochlear implant, or cerebrospinal fluid leak), a shorter interval of ≥8 weeks may be used to maximize protection more quickly.

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