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Common and uncommon etiologies of hypoglycorrhachia

Common and uncommon etiologies of hypoglycorrhachia
Etiologies commonly associated with hypoglycorrhachia Etiologies uncommonly associated with hypoglycorrhachia
(reported but not typical)
Infectious causes
  • Bacterial meningitis (including Nocardia and Brucella)*
  • Fungal meningitis*
  • Mycobacterial (tuberculous) meningitis*
  • Amebic meningoencephalitis
  • Cytomegalovirus-associated progressive polyradiculopathy or meningoencephalitis
  • Syphilitic meningitis
  • Lyme meningitis*
  • Viral meningitis
  • Neurocysticercosis*
  • CNS toxoplasmosis
Noninfectious causes
  • Carcinomatous meningitis*
  • Glucose transporter 1 deficiency
  • Leukemia/lymphoma with CNS involvement*
  • Subarachnoid hemorrhage*
  • Cholesterol-induced leptomeningitis secondary to Currarino syndrome*
  • Neurosarcoidosis*
  • Rheumatoid meningitis
  • Systemic lupus erythematosus with CNS involvement
  • Neuro-Behçet's disease
  • Dermoid cyst*
  • Granulomatous angiitis of the central nervous system
  • Malignant atrophic papulosis
  • Salicylate toxicity (uncertain association)
CNS: central nervous system.
* Etiologies reported to cause severe hypoglycorrhachia, generally defined as cerebrospinal fluid glucose level ≤10 mg/dL.
Original figure modified for this publication. Chow E, Troy SB. The differential diagnosis of hypoglycorrhachia in adult patients. Am J Med Sci 2014; 348:186. Table used with the permission of Elsevier Inc. All rights reserved.
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