| LUQ | Clinical features | Comments |
| Splenomegaly | Pain or discomfort in LUQ, left shoulder pain, and/or early satiety. | Multiple etiologies. |
| Splenic infarct | Severe LUQ pain. | Atypical presentations common. Associated with a variety of underlying conditions (eg, hypercoagulable state, atrial fibrillation, and splenomegaly). |
| Splenic abscess | Associated with fever and LUQ tenderness. | Uncommon. May also be associated with splenic infarction. |
| Splenic rupture | May complain of LUQ, left chest wall, or left shoulder pain that is worse with inspiration. | Most often associated with trauma. |
