| Systemic symptoms (fever >1 week, night sweats, weight loss [>10% of body weight]) |
| Supraclavicular (lower cervical) nodes |
| Generalized lymphadenopathy |
| Fixed nontender nodes in the absence of other symptoms; matted nodes |
| Nontender lymph nodes >1 cm with onset in the neonatal period |
| Nontender lymph nodes ≥2 cm in diameter that increase in size from baseline or do not respond to 2 weeks of antibiotic therapy |
| Abnormal chest radiograph (particularly mediastinal mass or hilar adenopathy) |
| Abnormal complete blood count (eg, lymphoblasts, cytopenias in more than 1 cell line) |
| Elevated lactate dehydrogenase |
| Absence of symptoms in the ear, nose, and throat regions |
| Persistently elevated ESR/CRP or rising ESR/CRP despite antibiotic therapy |
