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Opioid withdrawal syndrome

Opioid withdrawal syndrome
Drug Time course of opioid withdrawal symptoms following last dose
Onset Peak Nearly complete
Fentanyl (IV) 3 to 5 hours 8 to 12 hours 4 to 5 days
Heroin (diamorphine) (IV or inhaled) 8 to 12 hours 36 to 72 hours 7 to 10 days
Methadone 24 to 72 hours 4 to 6 days 14 to 21 days
Heroin (diamorphine) time course of abstinence symptoms approximates those for oxycodone, hydrocodone, codeine, and morphine.
IV: intravenous.
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