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Hyaluronidase-facilitated subcutaneous immune globulin (HyQvia): Initial treatment interval/dose ramp-up schedule

Hyaluronidase-facilitated subcutaneous immune globulin (HyQvia): Initial treatment interval/dose ramp-up schedule
Week Infusion number Dose interval Example for 30 grams per four weeks
1 First infusion One-week dose 7.5 grams
2 Second infusion Two-week dose 15 grams
3 No infusion
4 Third infusion Three-week dose 22.5 grams
5 No infusion
6 No infusion
7 Fourth infusion (if required) Four-week dose 30 grams
For patients switching from intravenous immune globulin (human) (IVIG) treatment:
  • After the initial dose ramp-up, administer HyQvia at the same dose and frequency as the previous intravenous treatment.
For patients naïve to immune globulin treatment or switching from immune globulin subcutaneous (human) (SCIG):
  • After initial ramp-up, administer HyQvia at 300 to 600 mg/kg at three- to four-week intervals.
Reproduced from: HYQVIA. US Food & Drug Administration (FDA) approved product information. Revised September, 2014. US National Library of Medicine. Available online at www.dailymed.nlm.nih.gov (Accessed December 3, 2015).
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