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Calculator: Dynamic International Prognostic Scoring System-Plus (DIPSS-Plus) for primary myelofibrosis (PMF) in adults and adolescents


Calculator: Dynamic International Prognostic Scoring System-Plus (DIPSS-Plus) for primary myelofibrosis (PMF) in adults and adolescents

 
Input
 

Age >65 years (1 DIPSS point)

Leukocyte count >25,000/microL (>25 x 109/L) (1 DIPSS point)

Hemoglobin <10 g/dL (<100 g/L) (2 DIPSS points)

Circulating blast cells ≥1% (1 DIPSS point)

Constitutional symptoms (1 DIPSS point)

Platelet count <100,000/microL (<100 x 109/L) (1 DIPSS-Plus point)

Anemia requiring transfusion (1 DIPSS-Plus point)

Unfavorable karyotype (1 DIPSS-Plus point)

 
Results
 
Important: Inputs must be complete to perform calculation.

 
 
DIPSS  
DIPSS-Plus  
 

 

 

DIPSS interpretation

 
DIPSS point count DIPSS risk category DIPSS-Plus points
0 Low risk 0
1 to 2 Intermediate-1 risk 1
3 to 4 Intermediate-2 risk 2
5 to 6 High risk 3

 

 

DIPSS-Plus interpretation

 
DIPSS-Plus score DIPSS-Plus risk group Median survival (all patients)* Median survival (patients <60 years)*
0 Low risk 15.4 years 20 years
1 Intermediate-1 risk 6.5 years 14.3 years
2 to 3 Intermediate-2 risk 2.9 years 5.3 years
4 to 6 High risk 1.3 years 1.7 years

 
 

 
Notes
  • Constitutional symptoms include:
    • Weight loss >10% of the baseline value in the year preceding PMF diagnosis
    • Unexplained fever or excessive sweats persisting for more than one month
  • Unfavorable karyotype includes:
    • Complex karyotype rearrangements
    • One or two abnormalities that include +8, -7/7q-, i(17q), -5/5q-, 12p-, inv(3), or 11q23
  • * Total DIPSS-Plus score was applied to a group of 793 consecutive patients with PMF seen at the Mayo Clinic, and in a separate analysis, the total DIPSS-Plus score was applied to a group of 299 patients <60 years seen at the Mayo Clinic.

 
Equations used
 
DIPSS = Age + WBC + Hb + Blasts + Constitutional symptoms
DIPSS-Plus = Plt + Anemia + Karyotype + Adjusted DIPSS

 

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

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All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

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