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Uptodate Reference Title
Algorithm for non-Rh(D) alloimmunized pregnancy
Algorithm for non-Rh(D) alloimmunized pregnancy
Refer to the UpToDate topic on non-Rh(D) alloimmunization in pregnancy for further details.
HDFN: hemolytic disease of the fetus and newborn; RBC: red blood cell; MCA-PSV: middle cerebral artery peak systolic velocity. * Cell-free DNA testing is performed on a maternal blood sample. In many countries including the United States, cell-free DNA testing for red blood cell antigens other than Rh(D) is not routinely available. In countries where cell-free testing is available, it is usually only done for Kell, Rh(c), Rh(C), and Rh(E). If cell-free DNA testing is not available, serial maternal antibody titers are obtained and amniocentesis is performed to determine fetal antigen status from amniocytes if/when the critical titer is reached.
