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Potential factors contributing to poor weight gain by age of onset

Potential factors contributing to poor weight gain by age of onset
Age of onset Potential contributing factors
Prenatal
  • Fetal (intrauterine) growth restriction
  • Prematurity
  • Prenatal infection
  • Congenital syndrome (metabolic or chromosomal)
  • Teratogenic exposure (eg, alcohol, anticonvulsant, tobacco smoke, caffeine)
Birth to 6 months
  • Poor quality of suck (whether breast- or bottle-fed) and/or oral motor dysfunction
  • Improper formula preparation
  • Breastfeeding problems, including insufficient milk supply
  • Inadequate number of feedings
  • Poor feeding interactions (eg, infant gags or vomits during feeding, caretaker misreads signals of hunger or satiety)
  • Child neglect
  • Parental mental illness
  • Metabolic, chromosomal, or anatomic abnormalities
  • Underfeeding (possibly related to poverty)
  • Milk protein intolerance
  • Cystic fibrosis
  • Congenital heart disease
  • Gastroesophageal reflux disease
7 to 12 months
  • Feeding problems, for example:
    • Autonomy struggles, particularly if caretaker is unduly anxious about intake or cleanliness
    • Oral motor dysfunction that interferes with adaptation to more textured foods
    • Delayed introduction of solid foods
    • Refusal to eat new foods when first offered so caretaker no longer offers
    • Caretaker does not offer adequate quantity or variety of solid foods
  • Intestinal parasites
  • Food allergies
>12 months
  • Coercive feeding
  • Picky eater
  • Highly distractible child
  • Distracting environment
  • Acquired illness
  • Social factors (eg, underfeeding related to fear of overfeeding, poverty)
  • New psychosocial stressor (eg, divorce, job loss, new sibling, etc)
  • Sensory-based feeding disorders in children with developmental disorders (eg, autism spectrum disorder)
  • Chewing or swallowing dysfunction
  • Excessive milk or juice intake
  • Caretaker does not offer enough quantity or combination of healthy foods
  • Celiac disease
References:
  1. Cardona Cano S, Hoek HW, Bryant-Waugh R. Picky eating: The current state of research. Curr Opin Psychiatry 2015; 28:448.
  2. Emond A, Drewett R, Blair P, Emmett P. Postnatal factors associated with failure to thrive in term infants in the Avon Longitudinal Study of Parents and Children. Arch Dis Child 2007; 92:115.
  3. Frank D, Silva M, Needlman R. Failure to thrive: Mystery, myth and method. Contemp Pediatr 1993; 10:114.
  4. McDougall P, Drewett RF, Hungin AP, Wright CM. The detection of early weight faltering at the 6-8-week check and its association with family factors, feeding and behavioural development. Arch Dis Child 2009; 94:549.
  5. Olsen EM, Skovgaard AM, Weile B, et al. Risk factors for weight faltering in infancy according to age at onset. Paediatr Perinat Epidemiol 2010; 24:370.
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