American Heart Association (AHA) | European Society of Cardiology (ESC) | British Society for Antimicrobial Therapy (BSAC) | |
Adult dose | Pediatric dose | Adult dose | Adult dose |
Aminoglycoside combination regimen¶ | Aminoglycoside combination regimen¶ | Aminoglycoside combination regimen¶ | |
Ampicillin 2 g IV every 4 hours for four to six weeksΔ or Aqueous penicillin G 18 to 30 million units per 24 hours continuously or in six divided doses for four to six weeksΔ plus Streptomycin◊ 15 mg/kg per 24 hours IV or IM in two divided doses for four to six weeksΔ | Consultation with a pediatric infectious disease expert is recommended in all cases of enterococcal infective endocarditis | Amoxicillin 200 mg/kg/day in four to six doses for four to six weeksΔ or Ampicillin 12 g per day (200 mg/kg per day) in four or six doses for four to six weeksΔ plus Streptomycin◊ 15 mg/kg per 24 hours IV or IM in two divided doses for four to six weeksΔ | Amoxicillin 2 g every 4 hours IV for four to six weeksΔ with or without Streptomycin◊ 15 mg/kg per 24 hours IM in two divided doses for four to six weeksΔ |
Beta-lactam combination regimen§ | |||
Ceftriaxone 2 g IV every 12 hours for six weeks plus Ampicillin 2 g IV every 4 hours for six weeks | Ceftriaxone 100 mg/kg per 24 hours IV in two divided doses or 80 mg/kg in one daily dose (maximum dose: 4 g per 24 hours; if dose is >2 g per 24 hours, use divided dosing every 12 hours) for six weeks plus Ampicillin 200 to 300 mg/kg per 24 hours IV divided in four to six divided doses (maximum dose: 12 g per 24 hours) for six weeks | Ceftriaxone 2 g IV every 12 hours for six weeks plus Ampicillin 2 g IV every 4 hours for six weeks |