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Uptodate Reference Title
CTLA-4 acting as physiologic "brake" on costimulation of CD8+ T cell
CTLA-4 acting as physiologic "brake" on costimulation of CD8+ T cell
CTLA4 outcompetes CD28 for CD80 and CD86, and the costimulatory signal ceases as the target is eliminated, reducing the release of pro-effector cytokines such as IL-12 and cytotoxic enzymes such as perforin and granzyme B. Homeostasis is restored.
CD: cluster of differentiation; CTLA-4: cytotoxic T-lymphocyte-associated protein 4; APC: antigen-presenting cells; MHC: major histocompatibility complex; IL: interleukin.
