| Dose | Category |
Acid suppression (IV)* |
Esomeprazole | Intermittent dosing: | PPI |
Infants: 0.5 to 1 mg/kg/dose IV once daily |
Children 1 to 17 years: |
<55 kg: 10 mg IV once or twice daily |
≥55 kg: 20 mg IV once or twice daily |
Adults: 40 mg IV twice daily |
Continuous IV infusion:[1] |
1 mg/kg IV bolus (maximum 80 mg), followed by infusion of 0.1 mg/kg/hour (maximum 8 mg/hour)¶ |
Omeprazole (IV preparation not available in the United States) | Children and adolescents:[2] 0.5 to 3 mg/kg IV daily in 1 or 2 divided doses (maximum 80 mg daily) | PPI |
Adults: 40 mg IV twice daily |
Pantoprazole | Intermittent dosing: | PPI |
Children and adolescents: |
<40 kg: 0.5 to 1 mg/kg IV once or twice daily |
>40 kg: 20 to 40 mg IV once or twice daily |
Adults: 40 mg IV twice daily |
Continuous IV infusion:[1] |
1 mg/kg IV bolus (maximum 80 mg), followed by an infusion of 0.1 mg/kg/hour (maximum 8 mg/hour)¶ |
Acid suppression (oral)Δ |
Omeprazole | Children and adolescents: 1 to 3 mg/kg daily[3] (maximum 80 mg daily) in 1 or 2 divided doses | PPI |
Adults: 40 mg twice daily initially, followed by 20 to 40 mg once daily (maintenance dose, once risk of recurrent bleeding is low) |
Esomeprazole | Infants 1 month to 1 year (daily): | PPI |
3 to 5 kg: 2.5 mg |
5 to 7.5 kg: 5 mg |
7.5 to 12 kg: 10 mg |
Children 1 to 11 years (daily): |
Weight <20 kg: 10 mg |
Weight ≥20 kg: 10 mg or 20 mg◊ |
Children ≥12 years and adults: 40 mg twice daily initially, followed by 20 to 40 mg once daily (as a maintenance dose, once risk of recurrent bleeding is low) |
Pantoprazole | Children 5 to 11 years: | PPI |
Weight 15 to 40 kg: 20 mg once daily |
Weight >40 kg: Use adult dose |
Children ≥12 years and adults: 40 mg twice daily initially, followed by 20 to 40 mg once daily (as a maintenance dose, once risk of recurrent bleeding is low) |
Vasoactive agents |
Octreotide | Children: 1 to 2 microgram/kg IV bolus (maximum 50 micrograms), followed by 1 to 2 microgram/kg/hour as a continuous IV infusion (maximum 50 micrograms per hour)[4]; initial bolus may be repeated once in the first hour if needed | Somatostatin analog |
Adults: 50 microgram IV bolus followed by a continuous IV infusion of 50 micrograms per hour; initial bolus may be repeated once in first hour if needed |