Calculator: Albumin-bilirubin (ALBI) grade estimate of survival of adults with hepatocellular carcinoma (conventional and SI units)

Input

Bilirubin
Albumin

Result

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ALBI score

Decimal precision

ALBI interpretation

ALBI score	ALBI grade	Median survival in months (newly diagnosed HCC patients)*	Median survival in months (treated with sorafenib)**
≤-2.6	A1	85.6	12.7
>-2.6 and ≤-1.39	A2	46.5	7.2
>-1.39	A3	15.5	3.6

Notes

* Median survival for all HCC patients including those who later had potentially curative surgery; results from initial Japanese training set from which the ALBI model was derived.
** Median survival for HCC patients with unresectable or relapsed incurable disease; based on data from clinical trials of sorafenib in HCC.
HCC: Hepatocellular carcinoma.
Please refer to UpToDate topic reviews for additional information on the use of the ALBI grade estimate of prognosis for adult patients treated for hepatocellular carcinoma.

Equations used

ALBI_score = (log(Bilirubin[mcmol/L]) * 0.66) - (Albumin[g/L] * 0.085)

References

Johnson PJ, Berhane S, Kagebayashi C, et al. Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Evidence-Based Approach-The ALBI Grade. J Clin Oncol 2015; 33:550.

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Topic 100996 Version 7.0