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Suggested classification of Clostridioides difficile infection in children*

Suggested classification of Clostridioides difficile infection in children*
Mild Moderate Severe Fulminant
  • Afebrile
  • Diarrhea (without systemic findings)
  • Fever
  • Profuse diarrhea
  • Abdominal pain
  • Fever
  • Profuse diarrhea
  • Abdominal pain and tenderness
  • Abdominal distention
  • Leukocytosis (white blood cells >15,000 cells/microL)
  • Elevated age-adjusted creatinine level
  • Pseudomembranous colitis
  • Hypotension
  • Shock
  • Ileus
  • Toxic megacolon
* There is no consensus definition of severe C. difficile infection in children. Determination of disease severity should be guided by clinician judgment.
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