Drug | Dose | Duration |
Topical therapies | ||
Various azole antifungal preparations (including creams, solutions, lotions, foams, and gels)* | Once- or twice-daily application | Typically two weeks (range in clinical studies of one to four weeks) |
Ketoconazole 2% shampoo | One five-minute application daily | Three consecutive days (a single application may be similarly effective) |
Terbinafine 1% cream | Twice-daily application | One week |
Ciclopirox 0.77% cream | Twice-daily application | Two weeks |
Selenium sulfide 2.5% shampoo | One ten-minute application daily | One week |
Zinc pyrithione 1 or 2% shampoo | One five-minute application daily | Two weeks |
Oral therapies¶ | ||
Fluconazole | 300 mg orally once weekly | Two weeks |
Itraconazole | 200 mg orally once daily | Five days |
* Topical azole antifungals include: clotrimazole 1%, econazole 1%, efinaconazole 10%, ketoconazole 2%, luliconazole 1%, miconazole 2%, oxiconazole 1%, sertaconazole 2%, and sulconazole 1%. For additional detail on available formulations and frequency of application refer to the Lexicomp drug-specific monographs included with UpToDate.
¶ Oral therapy is reserved for patients with disease refractory to topical therapy or widespread disease that makes the application of topical therapy difficult. Oral terbinafine and griseofulvin are not effective; oral ketoconazole is not recommended (refer to topic discussion). Doses provided are for adults.