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The International Classification of Sleep Disorders (ICSD)-3 criteria for Kleine-Levin syndrome

The International Classification of Sleep Disorders (ICSD)-3 criteria for Kleine-Levin syndrome
Diagnostic criteria
Criteria A-E must be met
A. The patient experiences at least two recurrent episodes of excessive sleepiness and sleep duration, each persisting for two days to five weeks.
B. Episodes recur usually more than once a year and at least once every 18 months.
C. The patient has normal alertness, cognitive function, behavior, and mood between episodes.
D. The patient must demonstrate at least one of the following during episodes:
  1. Cognitive dysfunction.
  2. Altered perception.
  3. Eating disorder (anorexia or hyperphagia).
  4. Disinhibited behavior (such as hypersexuality).
E. The hypersomnolence and related symptoms are not better explained by another sleep disorder, other medical, neurologic, or psychiatric disorder (especially bipolar disorder), or use of drugs or medications.
Reproduced with permission from: American Academy of Sleep Medicine. The International Classification of Sleep Disorders, 3rd ed, Chicago, IL 2014. Copyright © 2014 American Academy of Sleep Medicine. All rights reserved.
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