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Spectrum of neurologic and genetic disorders reported in association with Kleine-Levin syndrome (KLS) symptoms

Spectrum of neurologic and genetic disorders reported in association with Kleine-Levin syndrome (KLS) symptoms
Brain pathology Number of cases
Genetic or developmental diseases 7
Asperger syndrome 2
Cortical dysplasia and retinitis pigmentosa 1
Prader-Willi syndrome 1
Mosaicism with Robert's syndrome* 1
Intellectual disability and pyramidal syndrome 1
Intellectual disability, incontinentia pigmenti, acanthosis nigricans, and hereditary exostosis 1
Stroke 5
Traumatic hemorrhages of the right hemisphere 3
Multi-infarct dementia 1
Thalamic ischemic stroke 1
Infectious encephalitis 3
Others: multiple sclerosis, paraneoplastic syndrome, autoimmune encephalitis, hydrocephalus 1 case each
* Phocomelia, mild intellectual disability, optic atrophy, and bilateral facial palsy.
Source: Arnulf I, Zeitzer JM, File J, et al. Kleine-Levin syndrome: A systematic review of 186 cases in the literature. Brain 2005; 128:2763.
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