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Our suggested approach to testing for thrombophilia in pediatric patients

Our suggested approach to testing for thrombophilia in pediatric patients
This figure summarizes our suggested approach to thrombophilia testing in children and adolescents and is intended for use in conjunction with other UpToDate content. Refer to UpToDate's topic on thrombophilia testing in children for additional details and for the rationale behind this approach.
VTE: venous thromboembolism; CVC: central venous catheter; IT: inherited thrombophilia; OCP: oral contraceptive pill; Ig: immunoglobulin.
* For children and adolescents who have a strong family history of VTE or IT (eg, VTE in a first-degree relative <40 years old), we suggest IT testing only if there are additional risk factors or underlying medical problems that place them at risk for thrombosis (cancer, CVC, trauma, major surgery, current OCP use or considering OCP use).
¶ Acquired risk factors for VTE include malignancy, CVC, trauma, major surgery, oral contraceptives, and prolonged immobilization (among others). For further details, refer to separate UpToDate content on VTE in children.
Δ Antiphospholipid antibody testing includes immunoassays for IgG and IgM antibodies to cardiolipin and beta-2-glycoprotein-I and functional assay for the lupus anticoagulant phenomenon. For further details, refer to separate UpToDate content on diagnosing antiphospholipid antibody syndrome.
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