| Organ system affected | Symptoms due to acute and/or chronic mast cell-mediator release | Symptoms, physical findings, and abnormalities of routine laboratories due to organ infiltration |
| Skin | Flushing, pruritus | Multiple: Urticaria pigmentosa, plaque-like or nodular lesions, diffuse skin involvement, bullous eruptions, isolated mastocytoma, or telangiectasias |
| Gastrointestinal tract | Nausea, bloating, chronic diarrhea, hyperacidity, gastroduodenal ulcer disease, chronic abdominal pain, vomiting | Stomach and duodenal infiltration: Gastroduodenal ulcers (possibly, although more clearly related to mediator release), steatorrhea, malabsorption Liver infiltration: Elevated transaminases, portal hypertension, and ascites (only in advanced forms of the disease) |
| Musculoskeletal* | Adults: Fibromyalgia-like diffuse musculoskeletal pain, pain in long bones, osteoporosis, osteopenia, pathologic fractures | In mast cell sarcoma of the bone (rare), local symptoms (eg, pain, deformity, pathologic fracture) occur at the involved site |
| Cardiovascular | Adults: Episodes of vasodilation, tachycardia, hypotension, collapse Infants: Apneic spells, cyanosis | |
| Hematologic (lymph nodes, spleen, bone marrow) | Lymph nodes and spleen: Lymphadenopathy, splenomegaly (with hematologic findings of hypersplenism: nonimmune hemolytic anemia) Bone marrow: Anemia (mild-to-moderate, in approximately 50%), thrombocytopenia (usually asymptomatic), eosinophilia (approximately 25%), myeloproliferative or myelodysplastic findings, fibrosis | |
| Neurologic, psychiatric | Adults: Anxiety, depression, headache, mood changes, inability to concentrate, hypersomnolence, irritability, "mixed organic brain syndrome" Children: Aggressive behavior | |
| Systemic* | Adults: Fatigue, cachexia |
