| Absolute |
| Risk of infectious agent |
| Detection of gastrointestinal pathogens in stool (including Clostridioides [formerly Clostridium] difficile) |
| Known HIV, hepatitis B, C, or active syphilis infections |
| Known exposure to HIV or viral hepatitis (within the previous 12 months) |
| High-risk sexual behaviors |
| Use of illicit drugs |
| Tattoo or body piercing within six months |
| Incarceration or history of incarceration |
| Known current communicable disease (eg, upper respiratory tract infection) |
| Risk factors for variant Creutzfeldt-Jakob disease |
| Travel (within the last six months) to areas of the world where diarrheal illnesses are endemic or risk of traveler's diarrhea is high |
| Known colonization with or risk factors for multi-drug resistant organisms in stool |
| Gastrointestinal comorbidities |
| History of inflammatory bowel disease |
| History of IBS, idiopathic chronic constipation, or chronic diarrhea |
| History of gastrointestinal malignancy or known polyposis |
| Factors that can or do affect the composition of the intestinal microbiota |
| Antibiotics within the preceding three months |
| Major immunosuppressive medications (eg, calcineurin inhibitors, exogenous glucocorticoids, biological agents, etc) |
| Systemic antineoplastic agents |
| Additional recipient-specific considerations |
| Recent ingestion of a potential allergen (eg, nuts) where recipient has a known allergy to this (these) agent(s) |
| Relative exclusion criteria that might be appropriate to consider |
| History of major gastrointestinal surgery (eg, gastric bypass) |
| Metabolic syndrome |
| Systemic autoimmunity (eg, multiple sclerosis, connective tissue disease) |
| Atopic diseases including asthma and eczema, eosinophilic disorders of the gastrointestinal tract |
| Chronic pain syndromes (eg, chronic fatigue syndrome, fibromyalgia) |
