| Medication | Low dose (oral) | Standard dose (oral) |
| Histamine 2 receptor antagonists* | ||
| Famotidine | 10 mg twice daily¶ | 20 mg twice dailyΔ |
| Nizatidine | 75 mg twice daily◊ | 150 mg twice daily |
| Cimetidine§ | 200 mg twice daily¶ | 400 mg twice dailyΔ |
| Proton pump inhibitors | ||
| Omeprazole | 10 mg daily | 20 mg daily¶ |
| Lansoprazole | 15 mg daily¶ | 30 mg daily |
| Esomeprazole | 10 mg daily¥ | 20 mg daily¶ |
| Pantoprazole | 20 mg daily¶ | 40 mg daily |
| Dexlansoprazole | Not available | 30 mg dailyΔ |
| Rabeprazole | 10 mg daily¥ | 20 mg daily |
GERD: gastroesophageal reflux disease; US: United States.
* Histamine 2 receptor antagonists require dose adjustment in the setting of renal insufficiency.
¶ Available without a prescription (over the counter) in the US.
Δ The daily dose for erosive esophagitis with symptoms of GERD in the US prescribing information is up to twice the standard dose shown in this table.
◊ Strength not available in US. Available elsewhere.
§ Significant drug interactions can occur. When initiating or altering drug therapy, use of a drug interactions database, such as Lexicomp drug interactions, is advised. Other histamine 2 receptor antagonists with more favorable adverse effect profiles and fewer drug interactions (eg, famotidine) are generally preferred.
¥ Dose strength limited to certain dosage forms (eg, granules for oral suspension or sprinkle capsule). Consult local product availability.