| Profound progressive weakness |
| Bed-bound state |
| Sleeping much of the time |
| Indifference to food and fluids |
| Difficulty swallowing |
| Disorientation to time, with increasingly short attention span |
| Low or lower blood pressure not related to hypovolemia |
| Urinary incontinence or retention caused by weakness |
| Oliguria |
| Loss of ability to close eyes |
| Hallucinations involving previously deceased important individuals |
| References to going home or similar themes |
| Changes in respiratory rate and pattern (Cheyne-Stokes breathing, apneas) |
| Noisy breathing, pooling of airway secretions |
| Mottling and cooling of the skin due to vasomotor instability with venous pooling, particularly tibial |
| Dropping blood pressure with rising, weak pulse |
| Mental status changes (delirium, restlessness, agitation, coma) |
