| (A) The risk factor-based approach expressed as a point based scoring system, with the acronym CHA2DS2-VASc (NOTE: maximum score is 9 since age may contribute 0, 1, or 2 points) | ||
| CHA2DS2-VASc risk factor | Points | |
| Congestive heart failure Signs/symptoms of heart failure or objective evidence of reduced left ventricular ejection fraction | +1 | |
| Hypertension Resting blood pressure >140/90 mmHg on at least 2 occasions or current antihypertensive treatment | +1 | |
| Age 75 years or older | +2 | |
| Diabetes mellitus Fasting glucose >125 mg/dL (7 mmol/L) or treatment with oral hypoglycemic agent and/or insulin | +1 | |
| Previous stroke, transient ischemic attack, or thromboembolism | +2 | |
| Vascular disease Previous myocardial infarction, peripheral artery disease, or aortic plaque | +1 | |
| Age 65 to 74 years | +1 | |
| Sex category (female) | +1 | |
| (B) Adjusted stroke rate according to CHA2DS2-VASc score | ||
| CHA2DS2-VASc score | Patients (n = 73,538) | Stroke and thromboembolism event rate at 1-year follow-up (%) |
| 0 | 6369 | 0.78 |
| 1 | 8203 | 2.01 |
| 2 | 12,771 | 3.71 |
| 3 | 17,371 | 5.92 |
| 4 | 13,887 | 9.27 |
| 5 | 8942 | 15.26 |
| 6 | 4244 | 19.74 |
| 7 | 1420 | 21.50 |
| 8 | 285 | 22.38 |
| 9 | 46 | 23.64 |
