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Criteria for the diagnosis of possible multiple system atrophy

Criteria for the diagnosis of possible multiple system atrophy
A sporadic, progressive, adult (>30 years of age)-onset disease characterized by:
Parkinsonism (bradykinesia with rigidity, tremor, or postural instability) or
A cerebellar syndrome (gait ataxia with cerebellar dysarthria, limb ataxia, or cerebellar oculomotor dysfunction) and
At least one feature suggesting autonomic dysfunction (otherwise unexplained urinary urgency, frequency, or incomplete bladder emptying; erectile dysfunction in males; or significant orthostatic blood pressure decline that does not meet the level required in probable MSA) and
At least one of the additional features of possible MSA*
MSA: multiple system atrophy.
* Refer to UpToDate topics on MSA for additional features of possible MSA.
From: Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology 2008; 71:670. DOI: 10.1212/01.wnl.0000324625.00404.15. Copyright © 2008 American Academy of Neurology. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.
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