Corticobasal degeneration | Progressive supranuclear palsy | Parkinson disease | Multiple system atrophy | |
Age at onset, years | 45 to 77[1] | 65 to 75 | 65 to 80 | 50 to 60 |
Resting tremor | No | No | Characteristic | Sometimes |
Action tremor | Sometimes | No | Sometimes | Yes |
Asymmetry | Characteristic | No | Frequent | No |
Dystonia | Focal | Axial | Sometimes | Bilateral |
Memory | Sometimes | Sometimes | Sometimes | Sometimes |
Aphasia | Often | No | No | No |
Apraxia | Characteristic | Sometimes | No | No |
Alien hand | Characteristic | No | No | No |
Behavior | Disinhibited | Apathetic or disinhibited | Impulsive | No |
Cognitive | Parietal | Slowing, dysexecutive | Dysexecutive | Dysexecutive and others |
Autonomic | No | No | Moderate | Severe |
Gaze palsy | Often | Characteristic | No | Sometimes |
Pseudobulbar | Sometimes | Yes | No | No |
Falls | Later | Earlier | Later | Earlier |
Duration (median) | 6 to 8 years | 6 to 12 years | 6 to 22 years | 6 to 10 years |