| Skin |
| Feeling of warmth, flushing (erythema), itching (may begin on palms and soles), urticaria, angioedema, morbilliform rash, and "hair standing on end" (piloerection) |
| Infants and children - Eczematous flare |
| Oral |
| Itching or tingling of lips, tongue, or palate |
| Edema of lips, tongue, uvula, metallic taste |
| Infants - Drooling |
| Children - Rubbing tongue against pruritic palate, scratching tongue with hand |
| Gastrointestinal |
| Nausea, abdominal pain (colic, cramps), vomiting (large amounts of "stringy" mucus), and diarrhea |
| Difficulty swallowing* |
| Respiratory |
| Laryngeal - Pruritus and "tightness" in the throat, dysphagia, dysphonia and hoarseness, and sensation of itching in the external auditory canals |
| Lung - Shortness of breath, dyspnea, chest tightness, deep or repetitive cough, and wheezing |
| Nose - Itching, congestion, rhinorrhea, and sneezing |
| Cardiovascular |
| Feeling of faintness or dizziness; syncope, chest pain, palpitations, and/or hypotension (tunnel vision, difficulty hearing) |
| Neurologic |
| Anxiety, apprehension, sense of impending doom, seizures, confusion |
| Infants - Lethargy, hypotonia |
| Children - Abrupt cessation of activity, fetal position |
| Ocular |
| Periorbital itching, erythema and edema, tearing, and conjunctival erythema |
| Other |
| Lower back pain due to uterine cramping in women |
| Children - Ear pulling as an indication of pruritus |
| Vital signs/other objective measures |
| Pulse oximetry, respiratory rate, peak flow, pulmonary function testing |
| Pulse, blood pressure |
