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Differential diagnosis of cholestatic jaundice: Intrahepatic

Differential diagnosis of cholestatic jaundice: Intrahepatic
Acute hepatocellular
Viral hepatitis
Alcohol-associated fatty liver and/or hepatitis
Non-alcoholic steatohepatitis
Drugs
Chronic hepatocellular
Primary sclerosing cholangitis
Primary biliary cholangitis
Drugs
Hepatitis (viral, alcohol, autoimmune)
Cirrhosis of any cause
Multifactorial
Total parental nutrition
Systemic infection
Postoperative
Sickle cell disease/crisis
Organ transplantation (rejection; graft-versus-host disease; venoocclusive disease)
Miscellaneous
Hypotension/hypoxemia/HF
Budd-Chiari syndrome
Parasitic infection (Clonorchis sinensis; Fasciola hepatica)
Idiopathic adulthood ductopenia
Other cholangiopathies (IgG4 cholangiopathy; ischemic cholangiopathy; COVID-19)
Inherited/endocrine
Benign recurrent intrahepatic cholestasis (BRIC)
Progressive familial intrahepatic cholestasis (PFIC)
Low phospholipid-associated cholestasis (LPAC)
Thyrotoxicosis
Alagille syndrome
Disorders of carbohydrate, lipid, or bile acid metabolism
Caroli's disease
Pregnancy
Protoporphyria
Infiltrative/granulomatous
Amyloidosis
Lymphoma*
Sarcoidosis
Tuberculosis
* Rarely patients with lymphoma may have hyperbilirubinemia (direct) in the absence of tumor involvement of the liver or extrahepatic obstruction.
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