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Coagulation factor levels required for hemostasis and plasma half-life

Coagulation factor levels required for hemostasis and plasma half-life
Factor Plasma half-life Hemostatic level*
Fibrinogen 2 to 4 days 50 to 100 mg/dL
Prothrombin (factor II) 3 to 4 days 20 to 30%
Factor V 36 hours 15 to 20%
Factor VII 4 to 6 hours 15 to 20%
Factor X 40 to 60 hours 15 to 20%
Factor XI 40 to 70 hours 15 to 20%
Factor XIII 11 to 14 days 10 to 15%
Factor V + factor VIII combined deficiency 36 hours for factor V and 10 to 14 hours for factor VIII 15 to 20%
Multiple vitamin K-dependent factor deficiencies (factors II, VII, IX, X) ​Refer to individual factor half-lives above 15 to 20%
Refer to UpToDate topics on factor XI deficiency, rare inherited coagulation disorders, and fibrinogen disorders for details.
* Level of factor activity generally required for hemostasis, expressed as a percent of normal except for fibrinogen, which is expressed in mg/dL.
¶ Higher levels of factor VIII needed post-surgery.
Adapted from: Mannucci PM, Duga S, Peyvandi F. Recessively inherited coagulation disorders. Blood 2004; 104:1243. Copyright © 2004 American Society of Hematology.
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